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1.
To leave your hot wife for a hotter but insane and possibly homicidal girlfriend.
"Aww dude, don't McNair Cari! Melissa owns seven guns!"
by Dedzpot July 07, 2009
 
2.
Used to declare dominance in regards to riding in the seat directly behind the front right seat in a vehicle. This is because that seat is behind the "shotgun" position.
4 friends walk up to a car.

Person 1: I call shotgun

Person 2: I call Mcnair

Person 3: damn, now I have to sit behind the driver.

This is because of how mcnair was behind a shotgun..

too soon?

Call "cobain" instead..
by UTEXAS January 24, 2010
 
3.
The word McNair can be used as a substitute for any word.
"Those shoes are so McNairin'!"
"That girl is such a McNair!"

by Smai the Spy January 27, 2008