Mastrantonio Share definition Flag A Mastrantonio is a very hairy person. He is referred to by African Americans as "the hair nigga" "Damn yo, he be the ill Mastrantonio" or "such a good mastrantonio!" Mastrantonio by Sugar Sean April 10, 2003 0 0 Get merch Get the Mastrantonio mug. Buy Now — $32.95 See more merch