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2.
Acronym: "Laughing my ass fat off"

(v.) - to laugh so hard that you are ultimately burning fat from the butt.
LMAFO, that was the greatest video that i've ever seen!

Wow..that girl's got a giant badonkadonk....LMAFO
by OOJG March 31, 2007
 
1.
Laughing my ass the fuck off
LMAFO, that is too funny
by Robicleez October 20, 2011
 
3.
An abbreveation for "laughing my fucking ass off".

Used on the internet.
User 1: Goddamnit. Last weekend I didn't eat for 24 hours because I was too lazy to make some food.

User 2: lmfao
by klosterdev October 30, 2004