To destroy, damage, wreck, ruin, or generally f*** something up to the point that it's unusable, or to f*** someone up or pop a cap in their ass. Can also be used to refer to doping a racehorse or an athlete.

"What's the betting someone tries to knobble Golden Thunder before tomorrow's big race?" (Racehorse/Doping)

"I don't give a rat's ass whether he apologized. I want you to go and knobble Sammy the Squealer. Give him a long wet nap." (Mafia/Gangster/destroying someone)
"What's the betting someone tries to knobble Golden Thunder before tomorrow's big race?" (Racehorse/Doping)

"I don't give a rat's ass whether he apologized. I want you to go and knobble Sammy the Squealer. Give him a long wet nap." (Mafia/Gangster/destroying someone)
by Sid the sneaker May 28, 2013
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Small knob aka micropenis or prepubescent dick.
"That guy who tried to chat me up had a knobble, it was tiny!"
by Ignitedwhisper June 5, 2020
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Slang word for 'Knob'.
"Davey is such a dick"
"I know, he is such a knobble!"
by Vic and Kate Stanley August 3, 2005
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To be completely screwed over by the world and/or another person

i'm completley knobbled! I havn't done my homework
by Jono The Great July 13, 2006
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When you land a 98% but it doesn't matter because you wanted a 100. Based off the Geometry Dash Fail on Bloodlust when the Player Knobbleboy died at 98%
Ling: Darn it! I got a 98 on my test my parents are going to kill me!
Mason: Thats a Knobble
by NotA10YearOld May 13, 2018
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The act of rubbing ones penis discreetly in public. Can be performed outside or inside the pants. Can be a short knobble or a longer rub and stroke. Different from masterbation as the intent is not to reach climax, but instead more like scratching or rubbing yourself lightly between pleasurable short term rubbing near or on the erogenous zone. Often performed on a couch, often while watching TV, usually in the company of men but not always.
Damien is knobbling while watching Fox Sports again, I can smell it from here.
by old man peterson January 16, 2015
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Weak kneed from lack of sex.
Please don't be gone so long I get knobbly.
by Groggy Garbad January 18, 2011
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