Top Definition
Only when the following two conditions are met: First, a state in one's life were nothing of any importance is happening and no real effort is being put into one's life to change it. Second, a total lack of interest in taking any advice from anyone who would know any better then they do. Usually occuring in women going from there older teens to their adulthoods.
Manny: "How come she seems that she doesn't want to do anything with her life?"
Mark: "No its not that she doesn't want to do anything, shes just suffering from Jessica Syndrome."
by Andres Gonzalez February 08, 2008
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