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- Mix of the words 'ghetto' and 'spastic', meaning someone whom believes one is ghetto and/or gangsta but in reality is a retard.

- To be gangsta livin' in da hood AKA da ghetto.
"Man, that Jimmy person is a real ghettoistic!"

"Dawg, I be ghettoistic, foo'!"
by Yonasu June 28, 2008
Having most all of the traits needed to be considered ghetto. Similar to ghettofabulous.
50 Cent is very ghettoistic.
by Cody Stuckenschneider January 18, 2008