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1.
The feeling of sadness Notre Dame students feel when away from campus. It's a pun on homesick based on the Golden Dome on ND's main building.
After I graduated, I was so domesick.
by cflmo August 02, 2011
 
2.
experiencing a longing for receiving oral sex during a period of absence from it, a la "homesick"
I hate that I moved 1000 miles away from my girlfriend. I feel so domesick.
by lionelhutz September 25, 2010