Top Definition
Acronym for Center of the Universe Syndrome.
On a crowded sidewalk, she just stopped dead in her tracks, with no thought for anyone around or behind her, to answer her cell phone. What a COTUS!

He spent 15 minutes at the drive thru window, just chatting away, not the least bit concerned with those of us who only have an hour for lunch. He's suffering from a serious COTUS.
by tribblemaker January 28, 2013
1 more definition
an acronym for child of the universe.
don't fuck with these people unless you like to loose.
"who is that amazing human?"

"oh that's cotu, he/she is a wicked amazing sexy genius."
by zombse sutures August 22, 2008

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