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1.
1. To make fun of someone
2. To make someone's life difficult on purpose out of jest or with contempt, perceived or not.

"Don't get offended man, I'm just bustin' your balls!"

"I got my balls busted last night by my wife nagging me."

"It's just funny to bust balls with someone who gets easily mad."

by Rrrj1435 October 15, 2007
 
2.
To use a lot of effort to do something sometimes even in vain.
The cops will bust balls but thats it.
I busted my balls making him understand me but he acted wrong anyway.
by OlegK May 15, 2007