When a nice person has many attractive friends of the opposite sex, but all view him/her in a brotherly light, and have no romantic feels for him/her.
Although James had many female friends, he could not get any to date him because of his unfortunate case of brother syndrome.
by diodefuego August 27, 2010
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The act of making stupid mistakes over and over (usually at the same point) while trying to perform what should be a simple task. This most likely happens when doing things in a rushed manner.
Mario Brothers Syndrome:
Basically, in the original Super Mario Brothers for the Nintendo Entertainment System, trying to get through certain worlds hastily causes errors on the players part. Like hitting a turtle sideways and dying instead of jumping directly on it.
by Trace Faulkner September 3, 2008
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When one person feels they have a rivalry with another far superior person. The superior person usually doesn't know about it or feel that the little brother is any kind of a threat. The little brother usually puts forth maximum effort in meaningless situations in order to get the feeling of a win over his rival.
The Baltimore Raven's fans have little brother syndrome. They think they are the Redskin's rivals.
by persephone81 August 13, 2009
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OBS is when your guy-friend is wayyy too much like an older brother...overprotective, and hates anyone who touches you..or talks to you..or looks at you the wrong way. Sometimes as annoying as a sib, but you love them anyway:)
Guy: Hey gurl, wanna go out this weekend?

Girl: SURE!

Girls Best Guy-friend: Who is he? What does he want? Why is he talking to you?

Girl: Dude, chill it with the OBS (older brother syndrome)
by PIAFFE September 10, 2013
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An ingrained fear reaction that younger siblings show towards an elder. If properly nurtured can result in reactions such as flinching when the older sibling walks past even though the younger is taller, bigger and stronger and 18+. This can also result in a defeatist attitude and outcome when in confrontations with the older sibling.
Luke was a victim of little brother syndrome. Even though he was bigger, stronger, faster and a black belt in karate he could never defeat his older brother in a tickle fight. Luke is 20 years old.
by Rincow April 15, 2011
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When an older sibling brings a best friend into their home and the littler sibling thinks said person is their new friend and tries to impress them/flirt/or just won't leave you too alone for any reason
Your little brother has "Little Brother Syndrome" when he keeps trying to show your best friend his vast collection of Hot Wheels, even though said friend doesn't care and you both want him to go away.
by Dr. Upin Disbich July 5, 2015
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When a person(doesn't always have to be a sibling) idolizes something you have done and decides to follow in your footsteps, ultimately copying exactly what you have done; complete and juvenile lack of originality.
My friend has little brother syndrome. I began to pursue my dream of writing comic books, and not to my surprise, i find the hack doing exactly the same.
by xX Unwise Xx January 13, 2010
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