An alcoholic beverage consisting of Kaluha, Baileys Creme, and Vodka. Generally stacked in a shot glass to reveal the differeces in colors amoungst the layers.
Bartender, I'll take two more B-52s.
by JamieLynn August 9, 2005
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A practical joke disguised as a card game. You would ask your friend if they want to play a card game. They'd probably reply saying "Sure!". Now, you'd scream "52-Pickup!!" and chuck the cards across the room.
Me: Hey Trevon! Wanna play a card game?
Trevon: Yea, nigga, let's go.
Me: How about 52-Pickup?!?! *Throws the deck of cards at his cornrows* What now, bitch?
Trevon: Nigga, I'mma beat cho ass.
by Quilava126 October 28, 2007
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If you only see her face, she's fat.
Example:

Guy 1: see that! That face! She is so hot!

Guy 2: What about the rest of the picture?

Guy 1: Isn't there.

Guy 2: She's fat. Rule 52

Guy 1: Dammit!
by Random_is_me June 7, 2010
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jet powered strategic bomber still in sevice after 50 years, and still kicking some ass, dont fuck with us
and if you dont like it, that's tough beans go cry
our B-52s were succesful in demolishing the the war protestor encampment
by senor November 13, 2003
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The worst NES game that give other games next to it AIDS
Person 1:Is that action 52 on your shelf
Person 2:Yeah well you know
Person 1: Arent you scared that that game might give your good games AIDS?
by GamePlayer222 May 5, 2010
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A properly rolled joint that contains at least, if not more than, 1 gram of marijuana.
Holy shit dude, I was so fucked up after one B-52 last night.
by high ass roller March 24, 2011
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a band from the 80's known for their hit "Love Shack"
I've got me a chrysler, its as big as a whale and its about to set sail!! WHOO!
by jazz July 14, 2003
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