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1.
321
The Florida area code for Kennedy Space Center, Cape Canaveral, Cocoa Beach, and nearby areas. Coincidently it also represents the last three seconds of a space launch countdown. Making it very easy to remember.
I live in the 321 area code.
by 321 October 26, 2006
 
2.
321
countdown county
The area code for most of Brevard county, Florida: includes the Kennedy Space Center
unites the G's of Cocoa and Palm Bay and the Surfers of Beachside and the gayass emo bitches of Cuntree.
bitch, tha 321 got that funky krip nugs.
by abeck March 01, 2008
 
3.
321
3 hugs 2 kisses 1 love
okay babee i love you lots 321!
by mellissaa November 12, 2006
 
4.
321
When you disagree with someone or something, usually used on the internet.

This derived from chat rooms when people would typically ask you type in 123 if you agree with someone. For example "Press 123 if you like _______." People who would disagree would type the number backwards. It is not necessary to say you disagree, as it's a subtle enough sign of saying that you don't.
Jessica: "Press 123 if you're looking forward to the concert!"
David: "321"

John: "So who likes Dubstep and Rock mixed together?"
Jake: "321"
by Omega Royale March 25, 2013
 
5.
a method of smoking a joint in which every member of the circle takes three serrupticiously and holds them all,passes, and then two,passes, and then one,passes, and lets out once the new round has started.
"that 3 2 1 was heeaaavy!"
by ike December 03, 2003
 
6.
national ecstacy day
dude on 3-21 where gonna pop like 5 green music notes
by paul wheeler, adam weitzman September 26, 2007
 
7.
321
n. Used to describe someone who is retarded, moronic, stupid, inept, etc.
Derived from the disorder Trisomy 21, which is the cause for down syndrome. A handy phrase to use in public when you want to call something retarded, but the non-politically correct nature of the word doesn't allow you to do so.
Person 1: "Did you hear that Robbie failed all of his classes?"
Person 2: "Wow, what a fucking 321"
Person 1: "Such a 321... after I told him I failed one, he was like 'That's NOTHING, I failed ALL of mine.'"
by Snackrabbit December 02, 2009