The day after National Marijuana Day. Also known for parents as National Drug Test day.
Billy: I'm going to smoke a shitload of pot on 4/20!

Bob: Your parents are psycho. I'm sure they are gonna make you piss in a cup on 4/21.
by Fuzzy Pinata April 21, 2010
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Tom: Hey Billy, 4/20 was lit bro
Billy: Not for me, my parents gave me a surprise drug test on 4/21
by Kezsailu Gang April 6, 2016
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the day after national marijuana smoking day, the national pixie stick snorting day was established last year by Brandy and Emma.
shit bitchits 4/21, ima empty this pixie stick up my nose and snort it in the middle of the road while trying not to get my nigga ass run over.
by Emma and Brandy October 14, 2007
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Stoner # 1 - duude yesterday....highest i've ever been.
Stoner # 2 - welcome to 4:21 mannnnn
by osama bin blazen February 8, 2008
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When you forget to get weed for the actual 4/20, and can't find any because everyone is using theirs, or you are otherwise unable to celebrate on the actual day. So you therefore celebrate the day after...4/21
Sarah: Hey, do you have any weed?

Megan: No, and I can't find any from anyone else!

Sarah: Damn... 4/21?
by classy pseudonym April 20, 2010
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