When you yell and scream over everything.
My friend got Jacksepticeye Syndrome after I beat him in a game.
by Theft Tv May 25, 2015
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When you feel like you want to see S*** explode
Guy1: Im in such a jacksepticeye mood today,
Guy2: Just come to my place, i have some grenades
Guy1: why do you have grenades?
Guy2: because im always in a jacksepticeye mood.
by doggydoply45 May 25, 2015
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When someone, usually when gaming, yells and screams at their screen. They're normally loud but doesn't have to be to class as jacksepticeye syndrome. Not to be confused with anything about loving jacksepticeye or being a fan.
My friend got jacksepticeye syndrome when I beat him in a game.
by pseudony.com/index.html January 15, 2017
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Watching so much Jacksepticeye that you unintentionally fall in love with him.
I got a case of the Jacksepticeye syndrome. I mean, look how cute he is! I want to fuck his brains out.
by The British Bostonian November 16, 2016
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A person who thinks that making fun of someone when their dad dies is the funniest shit ever.
A video about why Sean "Jack" McLoughlin's dad deserved to die currently has quite possibly the lowest like-to-dislike ratio in the history of Youtube, with barely 200 likes and more than 11,000 dislikes; in other words, a ratio of roughly 0.01%.

To any of those Jacksepticeye Trolls: I hope your dad dies tomorrow and no one comes to their funeral.

Sincerely

The Internet
by Someone who kinda exists August 4, 2021
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Not your regular old youtuber. His talent is innate and he is the embodiment of innocence and hypercaffienated screams. Meme time and LAUGH are some of his best shows. He lives with his cat, Big Boss, and his girlfriend, Gab Smolders(Another wholesome youtuber). As of now, he has kinda sorta retired out of youtube- temporarily. He uploaded a short film named 15 months that showed his struggles and his creativity. Go check him out!
Do you know Jacksep-
TOP OF THE MORNING TO YA LADDIES! MY NAME IS JACKSEPTICEYE! AND WELCOME TO URBAN DICTIONARY!
by Truthisbitter July 29, 2021
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a fucking derp that re uploads jacksepticeyes videos
jacksepticeye mods is equal to keemstar
by the target hit January 21, 2017
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