bitch being slang for the main vain running down your arm in which heroin is usually injected.
smack is slang for the drug heroin.
put them together and you get smack my bitch up, in other words to inject heroin into your main vein in your arm.

also widely known from the famous song smack my bitch up by the prodigy.
hey man, im off to smack my bitch up whilst listening to smack by bitch up
by x-meow-meow-x April 2, 2008
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Quite possibly the single most controversial piece of electronic music ever produced. Released by The Prodigy in 1997, the lyrics consist entirely of eight words sampled from the classic hip-hop track "Give the Drummer Some." Four of those eight are, well, "smack my bitch up." The song has been interpreted as meaning a variety of things, ranging from shooting heroin to domestic violence to doing things intensely, the last of which is what the band maintains as the actual meaning.

The song was coupled with an equally controversial video, which depicts a wild night of sex, drugs, and violence from a first-person perspective. However, it was far from mindless- in fact, the video consistently ranks as one of the best ever made, and contains a twist that makes people rethink their entire interpretation of the song. Personally, I came away from it thinking the song was one big joke making fun of people who will dance to anything without caring what the lyrics are, but I'll let you decide for yourself.
Guy #1: Have you heard that song, "Smack My Bitch Up"?

Girl: OMG, that song is so offensive!

Guy #2: Yeah, but you have to admit, there's a lot worse. Just listen to rap music.
by WeHaveExplosive June 5, 2013
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To you completely impose your will on another with great authority
The Buckeyes have made Michigan their bitch for 13 of the last 14 years. In 2018, I will make you my bitch once again
by Tony45066 November 26, 2017
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It's the women's version of suck my dick, bitch!
You - wow, you look like a hot mess today! Whose bed did you crawl outta?

Me -Suck my bitch, dick!
by Misty Partly Cloudy June 15, 2022
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when shady says your dick is long so you clap them cheeks ya heard
you guys did you know that the new girl thicc bitch said my ding long crazy right
by slussysenis December 15, 2019
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1) What you say when you tell a nigga/cracka who frontin' to lay off your bitch.
2) should have been the title of that Nivea song...it wouldn't suck so much then.
1) Don't fuck with my bitch nigga or the pigs gonna find you and your family in a dark alley lyin' in chalk.
2) Don't fuck with my bitch, I'm a be the one to break it to you, got my niggaz and my bitch, so find yo own ho and leave mine alone yo.
by Nick D March 6, 2003
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The word you say to get a black girl to beat you and fuck you
"AYE Fucking nigga ass bitch suck my dick"

"What?"
by BigFatNigga October 29, 2021
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