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Fo Shizzle ma Nizzle

1) A phrase of agreement. Used when responding to a statement.

2) Another way of saying, "Of course." Used when responding to a yes/no question.

Both are heard in mostly urban areas, especially ghettos. Either that, or heard in an SUV driven by some white, suburban kid listening to rap.
1) Rodney: That was a great party last night!
Samuel: Fo shizzle ma nizzle!

2) Herman: Was that party last night great, or what?
Helga: Fo shizzle ma nizzle.

By the way, it appears many of the people who defined this word don't like black people. You might say that Rodney Basil doesn't like suburban, white people, but that's not so. I am a suburban, white person.
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nizzle pizzle 

An alternate form of "nigga please" used by non blacks in situations of high racial tension.
black man: "Yo honkey lips! You gonna join in this gang fight, or what?"

caucasian male: "Nizzle pizzle!"
nizzle pizzle by Honkey Lips February 4, 2010
Related Words

bust my nizzle on her fo'hizzle

To "bust" one's nut on a female's forehead.
As seen in Russell Simmon's Def Poetry Jam, delivered by Brother Jaime Foxx.

fo' shizzle ma nizzle

hey wanna go 2 da club 2nite?
fo' shizzle ma nizzle
fo' shizzle ma nizzle by soni June 14, 2004

Shizzle my nizzle 

Proof that society has got to the point that you can say retarded things like "shizzle my nizzle" without at least 13 people going "WTF?"
Shizzle my nizzle by Kay July 27, 2003
One of the many words that will not make one sound intellegent, cool, nor 'pimp.' Nizzle is a slang term for 'nigga' which was a term for a black slave, but now used as a slang term for black people to say to other blacks. If any other ethnicity uses 'nigga' the negro will be highly offended and will most likely 'cop your dome.' The word 'nizzle' was one of the many words to ruin the once-proud English language and has become one of the most annoying words in America. People who are most likely to use this word are nerds who want to sound cool, a black person who thinks nizzle sounds better then nigga, a wankster, white people who wished they were black, rapper wannabes, and people who wished they were someone like Usher.
Person #1: Dis nizzle is in tha hizzy!
Person #2: ...Tucker, what the f*ck are you babbling about?
Person #1: ...I said... "Dis nizzle is in tha hizzy!"
Person #2: Ok you just lost your speaking priviledges.
nizzle by Zaraki August 26, 2005