Evan: "Woah dude, I'm tweeking so much"
Nick: "I could tell, your legs have been moving every five seconds"
Nick: "I could tell, your legs have been moving every five seconds"
by SpareChange November 25, 2011
Get the Tweekingmug. by ThatSouthParkYaoi July 01, 2018
Get the Tweekmug. A character from the T.V show "South Park". He has very messy blonde hair and supposedly sufferes from A.D.D but his twitching and nervous personality is due to the large amounts of caffeine he consumes. In Series 6, Tweek became the main characters replacement for Kenny, alongside Butters, after he "permeanantly" died at the end of the previous series.
by Issy Aidsfunop January 22, 2006
Get the Tweekmug. 
to be overly excited at a situation or event that is highly positive and causes exuberance beyond classification of excitement.
Scott won a vacation to Hawaii, a place he always wanted to go, causing him to call his friends and tweek.
by BT14 August 03, 2007
Get the tweekmug. When a person who calls himself a business manager, steals people’s money, is paranoid from 15,000 dollars of crack in a burnt stem.
by Jaythereal December 21, 2022
Get the Tweekingmug.