A person who over indulges when taking psycho - stimulants, such as Adderall and crystal meth. Many become habitual users... meaning they leave less time in between each "run" so their brain never fully recovers like it did when it was just every now and then. Most brain damage, hallucinations, delusion, paranoia, anorexia, etc... is unlikely due to amphetamines alone. Tweekers don't sleep or eat. They can't continue to function. Tweekers lose their sense of Reality. Tweekers lie about everything, only because of how DEEP their self hate runs. Tweekers are sad that they are tweekers but see no point in quitting after so many years of frying their brain, losing loved ones, self pity, regrets, the list goes on forever. Just because you have " tweeked " once in a great moon doesn't make you a "tweeker" . But tweekers are Perma-tweeked.
The shy girl next door with the obvious lack of self-esteem tweeked on meth only twice last year. She was beautiful and had a great fashion sense. Now that she moved in with her dealer boyfriend. She started tweeking everyday, nonstop. In less than 6 month she lost her job, account, money, one tooth. And she was beautiful but 6 month of being a tweeket aged her, visually, 6 years. She's literally skin and bones with no muscle tone. I don't hate tweekers because I can alway see and smell one within 50 ft of me, so I don't associate with them because if you do... you can only blame YOU for being stupid enough to position a tweeker to burn you. They lie, steal, cheat, and believe most the lies. Stay away
by CamCordChic January 1, 2017
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A person who has worked their way to the second highest level of their methamphetamine career, tweekers have poor hygiene. The only level above a tweeker is a Cook who carries God like status among tweeker because the cook manufactures the crystal death that they all soo much love.
That tweeker hasn’t been off my couch for two weeks and hasn’t showered the whole time.

My TV has been stolen I bet it was that fucking tweeker.

by Auld man December 15, 2007
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a person who does meth or other hard chemical drugs
by marsi March 30, 2005
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An inhibitant of Co. Co. County, SF Bay Area. (see Danvillians) REPRESENT! Usually found skulking in bushes, trees or they dark garages the call, "Their Castles". Most common traits include: haircuts without scissors, surgery without a scalple, and spending countless hours of the night playing window nintendo! Some tweekers are a bit more fortunate, their game systems have been upgraded to home surveillance systems. Their mission in life is to obtain and comsume as much FUCKING CRANK AS WE POSSIBLY CAN!!!
Smoke crank! Fuckers.....
"You fucking tweeker, get the fuck out of the fucking window, they can see you!"
"Who's got my lighter?!?1"
"Bitch! There was more in this sac! Where the fuck did it go?"
"What's in the bowl bitch?!"
"Who's look'n?"
"Good ones"
"Pipetastic, pipetacular, spooftastic!!!
and last but not least .....
"Quiters never win, and winners never quit!

-Long Live Spriq's- (yellow lable)
by Redwood & Squiggles January 15, 2006
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A person, often a crystal meth user, who does completes every thing he/she begins far beyond the point of finished.
I should have known not to ask billy to fix my computer, he's been tweeking out on it for weeks!
by christy October 21, 2003
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Someone who steals from others in order to produce the funds to get high.
Hey man, never let Jimmy into your house! He's a notorious tweeker !
by 420 Boy February 4, 2018
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Constantly having to go to rehab to clear the court sentencing. Borrows money from friends and family(sister) and never ever pays it back. Always looking for rich people to date or marry to support there habit and low self-esteem.
Joanne Mio

Booty
Ho
whore
addict
loser
by Yeah_right March 16, 2005
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