1. Toe up is a term made popular in the teen dramady, "Clueless." Dione says that Ty is "... toe up; our stock would plummet." Meaning that Ty is lousy and useless, not to mentiondetrimental to social status. 2. Also can be taken as "upside down."
1. That guy is toe-up. Don't hang with him.
2. I was so toe-up for Paul, I can't believe he likes Shelly instead.
Slang for getting a women getting someSexual intercourse, Thus getting put on her back to be "toe up" (Mainly from The South of North America) feats. in a track on Outkast's album - Stankonia