1. An expression to refer to those Americans who live unexciting or unexotic existences. Typically used by truckers, construction workers, or others whose livelihoods aren't geographically dictated.

2. Boring middle class white people who live in suburbs.
Sam: All they do is bitch about their commute.
Bob: Of course. They're duffers. That's what they do. That's their biggest problem.
by mathias83 March 12, 2008
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Any person who has grey hair; Any person who spends 5 minutes stepping off a curb; Any person who can't, for crime's sake, drive faster than 25 miles per hour anywhere.
Holy Shiite! I almost ran into that dang duffer. He can't even see over the steering wheel, let alone the speedometer! Take the bus! Crime!!
by Gemilie August 16, 2006
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Pass us the duffer luv this programme's crap.
by Becca August 16, 2003
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Someone who goes into the jungle gets bitten by a tick or denge bug and catches a 5 day fever AKA jungle fever
I held on to the antibiotics incase I met sombody who would be such a tweedle duffer as to run though the jungle with no bug spray on.
by DemonWeapon April 15, 2017
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A slang term for the very serious medical condition duphershypertrophy whereby the sufferer acquires over time excessive fatty tissues to the nasal region, giving the patient the not unpleasant features of a gnomish looking fellow; rosy cheeks from the strain of holding one's nose up all day, at times somewhat gormless facial expressions (which can be attributed to the drag-factor but more often can lead an innocent bystander unaware of the condition to conclude that the sufferer is possibly some sort of simpleton) and of course the ever-expanding, bulbous nose which grows and grows like in that fable about the enormous turnip...

Prognosis: Not good; rhinoplasty recommended.
What are you doing resting your nose on that snooker cue? Have you got Duffers' Syndrome or something?
by Mouldy123 March 17, 2011
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