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Pre-ex refers to your ex boyfriend/girlfriend before the break up. Many people get confused when someone refers to their ex if they are talking about before or after the break up.

If a person says, "My ex burned my house down" you wouldn't know if the ex boyfriend/girlfriend burned the house down while they were still dating and that's why they broke up or if they broke up and then the ex boyfriend/girlfriend burned the house down.
Bro 1: Bro I made out with my Pre-ex a lot.
Bro 2: Nice, so who you making out with now?

vs

Bro 1: Bro I made out with my ex a lot.
Bro 2: Nice, you getting back together?
Pre-ex by Kentviknesh July 19, 2018

Pre-Ex Status 

A relationship along the same lines as friends with benefits, except that the male initiating the relationship pretends to have feelings for a woman just to engage in sexual intercourse with her.
Man 1: Yo, Man 2, you seen that one bitch at the shop?
Man 2: Hell yeah, I'd like to get to pre-ex status with that bitch.
Pre-Ex Status by Ditno October 3, 2011

Pre-Ex 'Sex' 

The mechanical, uninspired act of passionless intimacy dutifully completed by individuals who's long-term, expiring relationship has fatigued from overwork, emotional exhaustion, diverging interests or mutual contempt.
When you're given under 3 minutes to 'do yer business' while she answers emails and texts...the best Pre-Ex 'Sex'...EVER!
Pre-Ex 'Sex' by YAWA November 24, 2019

pre-exposure prophylaxis 

Pre-exposure prophylaxis (PrEP) is an effective HIV prevention medication that protects HIV-negative people from acquiring HIV. PrEP taken regularly, as medically prescribed, is proven to reduce the risk of acquiring HIV by over 90%.
If you're having bareback sex then you should consider being on Pre-exposure prophylaxis to lower your risks of acquiring HIV

PESE (Pre-Exam Shit Explosion) 

A condition for individuals who get extremely nervous right before taking an exam or test. The anxiety is so severe that they feel as though they need to run to the bathroom to take a shit before going forth with the exam.
Alex was suffering from PESE (Pre-Exam Shit Explosion) before the Physic's final exam.

Pre-existing condition 

An old flame you can’t help hooking up with periodically, regardless of either person’s relationship status.
Amy: I can’t believe you slept with Adam after the class reunion. He’s engaged and you have a boyfriend!

Lola: Hey it wasn’t my fault. Adam is a pre-existing condition.