A sleazy, often perverted individual. This term originated from the popular film series Mean Girls and its usage began officially when Regina George asked Jason why he was being such a "skeez" after he tried making fun of Cady Heron.
1. That Paris is a skeez. She sleeps with everyone, and then lets the video get on the net.
2. Lets see if we can get the chick drunk enough that she'll be a skeez.