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macaroni and cheese hamburger 

The best, yet most disgusting thing to whisper in your friends ear
O: Hey I gotta secret
P: what?
O: macaroni and cheese hamburger
P: *rips his organs out

hamburger with cheese

A cheeseburger in which the cheese was an after-thought. The cheese is placed on the patty after it is cooked, but before the top of the bun is placed on the hamburger, as opposed to the cheese being melted onto the patty while still on the grill (cheeseburger).
You: Excuse me waitress, I ordered a cheeseburger. This is clearly a hamburger with cheese.
Waitress: What's the difference?
You: Look it up on urban dictionary, skank.

Hamburger with cheese

When a vagina has an obscene amount of extra skin, it slightly resembles a quarterpounder with cheese.
Damn Gina, I never ordered a hamburger with cheese, why didnt you warn me about your monster clam?

humburgers with cheese 

Humburgers on a truly villainous scale, humburgers with cheese implies an extreme that few situations can achieve. See bah humburgers.
CIA: Mr. President, Iran may have nukes. In fact, they do. In fact, they're on their way here. In fact, they're hitting your dad's house right now.
President Bush: Ah, humburgers with cheese.
humburgers with cheese by Ruum December 1, 2004