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To ruin a situation. Damage something suddenly.
You will mess up the wedding if you decide idea to play the piano. You suck!
mess up by Favelasqa September 1, 2016

major league mess up 

Also known as a mlmu, it is used to describe a moment when someone (including yourself) humiliates themselves, reveals a secret they didn't want to reveal, says something bad, etc. In public or in front of the boys, and Is so bad that it can only be described as a major league mess up
Person 1: hey, did you hear that (famous person) said the n-word on their social media account?

Person 2: yeah bro, that was a major league mess up
To change something and bring its value to a lower degree.
I balled up LeBron James and took him to the hole in 1 on 1 10 times. I won the game 10-0. He told me I should play in the summer pro league. I said no way, nuh-uh, that shit might try to mess up my game.
Mess up by MatthewSzymanski December 18, 2020
Me
I am an Mess up
Mess up by Dakota Wilcox December 9, 2019

Nov 15 Don’t mess with ur short friends day 

So basically the people who made the days to annoy short people this day will have u annoy them and it’s on the 15 of nov
Nov 15 Don’t mess with ur short friends day U annoyed me and shorter so I get to slap u and hit u and annoy u

one hell of a gobbed up mess 

adj. - term used to describe the inevitable outcome of any home improvement project involving painting, caulking, foam insulating, grouting, mudding, etc.
Do It Yourselfer #1: "It looks like Helen Keller caulked this tub!"
Do It Yourselfer #2: "Yeah, it's one hell of a gobbed up mess."