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Macfarlane 

A Scottish name meaning I will kill you if you start trouble with my friends or my clan .
2.crazy muther scratcher that Will take great pleasure ripping your eye out so you can watch yourself getting your ass kicked .
Onlooker: Damn it man,what the the hell happened to you
Dumb ass that crossed the proverbial line:
I don't know I was shooting my mouth off and got MacFarlane'd
Macfarlane by gnarnold August 8, 2015
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MacFarlane 

The bloodiest of Scottish clans, deep devotion and loyalty
Don't mess with him, he's got the temper of a MacFarlane
MacFarlane by Fresria January 17, 2009

MacFarlane 

A highly ridiculous person who habitually ridicules others; an egotard.
"The creator of Family Guy is a total MacFarlane."
MacFarlane by O'Brian McFinnigan February 6, 2023

Sam Macfarlane 

Sam Macfarlane by Samsuxxxx March 15, 2017

Ed Macfarlane 

Ed Macfarlane is the lead singer of an amazing band called Friendly Fires, he is also known for being seriously attractive and one hell of a dancer.
i almost came when i saw Ed Macfarlane dancing in "Kiss of Life"
Ed Macfarlane by strfckr August 29, 2011

Seth MacFarlane 

The creator of Family Guy, American Dad, and The Cleveland Show.

While the earliest seasons of Family Guy were genuinely funny, the half-baked, arrogant, overly self-indulgent douchebag known as Seth MacFarlane now mostly uses it as a vehicle for his anti-religious opinions (stated as facts) and takes on social issues, which are usually projected through Lois. To make Family Guy more of a cartoon, and less of a rant on right-wing Christians, he sprinkles in bits of Peter's buffoonery, Stewie-is-gay jokes, random swear words, 70's and 80's movie references (which approximately 3 per cent of the show's mostly teenage and twenty-something douchebag audience understands), et cetera. American Dad and The Cleveland Show are not used as frequently for this purpose, and are more or less cheap spin-offs of Family Guy, with their respective characters filling in each family role (Peter = Stan = Cleveland, and so on).
Come on, Seth MacFarlane, that's just pathetic.

Seth MacFarlane 

The very bland, very unfunny, very unoriginal creator of Family Guy that Fox chose to bring back for another season instead of Futurama. (aka the LESS retarded more original and actually FUNNY show.)
*Making an episode of Family Guy*

Seth MacFarlane: Geez, guys. I'm running out of ideas for Family Guy.

Executive Producer: Hmm. Well maybe we can steal a scene from The Simpsons, then change it up a little bit so people will think it's original, like we always do!

Seth MacFarlane: Great idea!


Seth MacFarlane: Oh, and let's just stick another joke about Tom Cruise being gay in there like we did a million times already, even though South Park did it first. Or maybe make another joke about how Meg sucks.

Executive Producer: Hahahaha! That's hilarious! Yeah, okay, they'll think that's funny, too. Because jokes repeated over and over and over again are ALWAYS funny, right?