The C.A.N.S. is an acronym for Crazy Ass Nigga Syndrome or also referred to as the 'Chris Tuckers'. This syndrome is often brought upon with the presence of THC or extreme moments of excitement. Symptoms are: Louder more high pitched voice, Screaming, and yelling.
Joey: "Man paka really had the C.A.N.S. last night, he wouldn't stop yelling after we ripped from that bong"
Wade:"Damn Chris Tucker sure had the C.A.N.S. in the movie, friday"