Metropolitan Innundation Syndrome, or MIS, has two main manifestations.
The most prominent occurs when someone of rural or suburban origins travels to a large city. Symptoms include disorientation, slow reactions (as they are unused to the faster pace of life), respiratory problems (from polution), hearing loss and/or tinitus (caused by city noise), and eye strain (from excessive light exposure).
The second manifestation occurs when a city-dweller travels to suburbia or a rural area. The primary symptom in this case is boredome, and subsequent substance abuse or destructive behavior.
Type I: WTF? Where am I? All the streets look the same! I can't think with all this noise and light!
Type II: Dude! There's no Starbucks here! Let's get drunk and burn stuff.