A small mistake which causes a huge disastrous event to occur.
From an online game, where the creator Jick accidentally deleted the entire database with a single click.
"Dude, why did you have to spill those thumb tacks on my box of condoms? Now she's pregnant, and her parents beat the crap out of me and my wife found out about my affair and shot herself."
"Sorry, it was a Jick click."