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1. polite or not so polite way of telling someone to go do something else.

2. fuck off, shag off, wank off, get the fuck out, take a hike, get lost, scram, go diddle on your computer, beat it.
1. At the very moment Newman reached the fever pitch of agitating Kramer with trivial nonsense, Cosmo bellowed, "twitter off", turned his back and slammed the door.

2. Sammie ranted and raved and prevaricated until his host gnashed his teeth and suggested, "TWITTER OFF" in a low and menacing voice.
by gruntlestiltskin July 03, 2009
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