This is a sly reference to and synonym for the penis or cock. For males adding the penis to the 10 fingers and 10 toes makes 21 appendages. Use this if you want to sound intelligent or don't want stupid or younger people to know what you are talking about.
I'm in the process of writing an epic poem about the love between me and my twenty-first appendage.
by Kyle Bravlavski AKA Jewboy December 23, 2010
Get the twenty-first appendage mug.
Someone wealthy who throws parties like Gatsby today but with all the technology and fun that was around in the 20s and with the new culture.
Yeah he's the Twenty-First Century Gatsby.
by André10000 May 27, 2011
Get the Twenty-First Century Gatsby mug.