The law of total probability that decides it will be your turn to be without toilet paper in the bathroom.

All at the same time, there is not a spare roll within a 12-mile radius of your location. This may have you questioning what you did to deserve this or why bad things happen to good people.
"I prayed to God asking not to be hit with the Toilet Paper Conundrum."

"I still haven't recovered from that Toilet Paper Conundrum yesterday."
by homb July 4, 2014
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A problem occurring to you whilst you are on the toilet.
"Damn man, last night i had a panic attack while I was taking a shit, serious toilet conundrum."
by chrischanlover69 January 2, 2022
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