6 is the number for crips, so "shooting the 6" is the crip way for saying "fight". While bloods use "shoot the 5".
Rayshawn: "yo, we loc'in hard today, we about to shoot the 6 with some slobs"

Bob: "omg, I don't want to get hurt in crossfire"

Kevin: "shut the fuck up"
by Serious Bu$iness October 19, 2006
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