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Saponara 

This is the last name of an Italian. They are pretty special. Saponara's are very rare people to find. Once you find one, befriend them as fast as you can! Let me tell you, they're angels. They make you happy, have the best laugh, and will listen to you. Don't get me started on the food. Gosh, the spaghetti. It's amazing.
"No way, is that a Saponara?!"
"Yup, sure is"
"Wow, I better go say hi right away!"
Saponara by Your friend, November 23, 2021
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National hate gabby saponara day 

A day where everyone hates a girl named gabby saponara
Hey angelo it’s national hate gabby saponara day.

Angelo: good I don’t wanna talk to her

Tokyo Sayonara 

When you leave, but you only say goodbye to the cat.
I'd better leave soon, but that cat was too damn cute, let me pull a Tokyo sayonara.
Tokyo Sayonara by Utnanacorn April 24, 2018

sayonara motherfucker 

Something a person would say to another before he/she shoots the other person...

Sayonara Zetsubou Sensei

Probably one of the weirdest manga ever penned by the Japanese. Written by the satirist Koji Kumeta, it tells the tale of one Kafuka Fuura, who discovers her teacher, Nozomu Itoshiki, under a sakura tree...

He is hanging by the neck in one of his many suicide attempts. She, being endlessly optimistic, thinks he is simply trying to make himself taller. Needless to say, this is where things get quite strange...and hilarious.

He teaches a class full of strangers, from the hikikomori, to a Disassociative Personality Disorder suffering transfer student, to a stalker, to a ridiculously OCD psychopath. And a normal girl.

The series does not take itself seriously at all, and is probably the darkest, strangest, and most disturbing comedies in existence.

AND I LOVE IT.
I'M IN DESPAIR! THE FACT THAT SAYONARA ZETSUBOU SENSEI HAS ENDED HAS LEFT ME IN DESPAIR! THERE'S NO HOPE! I'M GOING TO GO DIE!

Sayonara Bitches 

Phrase used to announce that you are leaving the premises like a Boss and/or Badass
Inferior Co-Worker: Are you leaving?
Superior Self: Yeah, Sayonara Bitches
Sayonara Bitches by THAT Guy June 15, 2012

Sayonara 

Japanese for 'goodbye'; however, it carries more finality. Instead of being used at the end of a day, as in "Goodbye see you tomorrow," it would be used in situations where you will either not see the person for a long time, if ever again.
Man: I'm sorry my trip is taking me overseas for an indefinate amount of time, I will call you as often as I can!

Woman: Sayonara! *tear*
Sayonara by A Man Called Michael October 15, 2009