Run my shit 

to do what needs to be done or to take care of business.

Person one: "What are you gunna do today?"
Person two: "I gotta run my shit, bitch."

Run my shit by Dmoneykingca-ching May 27, 2010

run me my shits 

Basically when two people are having a confrontation and one of them wants to fight, they will say "run me my shits". It's a long way around just saying "fight me right now".

Bob fucks Jim's girlfriend*
Bob: Bro I didn't mean to fuck her

Jim: Run me my shits
They proceed to fight*

run me my shits by The passion of the christ February 5, 2017