Top definition
Occurs when you humiliate yourself and or devastate your career by inadvertantly replying to the wrong person or (worse, yet) mistakenly hitting the "reply to all" button in an email.
The boss was not laughing when he fired David after the embarrassing replyicide episode.

by M. J. Jenkins June 24, 2007
Get the mug
Get a replyicide mug for your grandma Rihanna.