Pistachio eyed means that you're so high (blazed) that your eyes start to look like pistachios. Your eye is the pistachio seed and your eye lids are the pistachio shell. The shell on a pistachio slighty covers the seed inside to where you can barely see it which resembles your eyes.
"Damn man! I'm so pistachio eyed!"
"Look at Leo, he is pistachio eyed!"

"Did you get pistachio eyed last night?"
by Emoore058 July 10, 2014
Get the Pistachio Eyed mug.