muddafucker is sort of 'slang' for Mother Fucker, which is an insult commonly used. muddafucker is often used in texting, memes, and social media instead of having to type the long-winded 'Mother-fucker'.
by FaFaFabulous May 07, 2016

an exclamation of extreme dislike, disdain, or unapproval of something. Also used as a very derrogatory curse
by BahamaboiNubcee March 07, 2010
