Spanish for "hand-to-hand". Used most commonly for a competition between two people - often in hand to hand combat.

The phrase is often mistakenly thought by English speaking people to mean "man-to-man".
In Spanish bullfights, the two matadors compete mano e mano for the admiration of the audience.
by gp26 December 06, 2010
Get a mano e mano mug for your dad Georges.
man to man, one on one, usually used in the context of a physical confrontation / altercation between two gentlemen.
okay, buddy, you and me, mano e mano.
by themarcuscreature February 21, 2005
Get a mano e mano mug for your mate Trump.