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Irony poisoning is when one's worldview/weltshauung/reality tunnel is so dominated by irony and detachment-based-comedy, that the joke becomes real and you start to do things that are immoral or wrong from a place of deep nihilistic cynicism.
"Why would John do this to me?"
"It's irony poisoning, ma'am. Seen it a million times."
by SRSLY WRONG May 24, 2014
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