Top definition
A one night stand often perpetrated between an extremely drunk man and an extremely ugly woman. Once the guy wakes up and realizes that he slammed a fatty/uggo he immediately runs away. It is also quite commonly linked to the walk of shame. Just make sure no one finds out about your hump and run.
Daryl: I was so wasted last night.

Steve: Hell yeah you were! I saw you leave with that whale. A little hump and run eh?

Daryl: You saw her.....?

by Mr. Bladder June 29, 2010
Get the mug
Get a hump and run mug for your buddy Beatrix.