When a person's face is so bloated and deformed that it's impossible to distinguish it from their ass. As it is, the ass already resembles a hippopotamus face. For the poor bastard sporting one of these, it also resembles theirs. It is a synonym with "Ed Zachary Disease".
Yikes - look at that double hippopotamus. If he ate with his ass and sat on his face, I wouldn't know the difference.
Ryan: When I got home I found out that girl from the bar last night, was a major hippotwatamus
Jeff: Oh yeah, I went on spring break with her and wasn't sure if she had a penis or not.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.