Also used to refer to people, with the same connotation as other slang terms for vagina. Intended to insult the person's bravery or manhood. Still spelled with an enyeah.
"Did Tom go on the ride with the rest of them?"

"No, he was a total Guana."
by racingrickster April 21, 2006
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A slang term for the vagina. Usually used to refer to particularly unappealing vaginas. Is spelled with a accent called an "enyeah"
I saw Oprah getting out of a limo yesterday, and when she stuck her leg out, I totally saw Oprah's guana.
by racingrickster April 21, 2006
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An islet located in The Bahamas. It is a long but narrow islet which is 9 miles in length. There is a five and a half mile long beach on the ocean side of the island which is one of the longest in the Bahamas. There is a cove located on the island called Kidd's Cove named after a pirate. The island has a population of approximately 150 people who live on a settlement which stretches along the beach. Basically the best place EVER!!!
Great Guana Cay is the best island in the WORLD!
by TweetyGGC July 11, 2009
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a mixture of 5 sexually transmitted diseases and one rare blue vagina thing found on the internet. Usually obtained from gang bangs in Mexican jail cells and or giant sea turtles.
Jim: Yo Dewd i finally got out of that nasty ass jail cell below the border.
Alberto: FUCk yo that must have sucked did you get swine flu?
Jim: nah but i got raped by 4 guys and now i have s.h.g.c.b.a.
Alberto: wahtt?
Jim: Syphili-herpe-guana-clamida-bluewaffle-aids. pretty common actually.
by Mr.calvin April 22, 2010
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