1.a crazy motherfucker. 2. A devoted fan of Slightly Stoopid and member of their street team.
G: "Stop playing around wit me son or I'm gonna slit open yo bitch ass gizzad..."

Juan: "Hey take it easy homes! No need to act all ese loco n' shit."


Stoner Sam: Hey bro, you going to see Stoopid in Philly?

Harry Hed: Fuck ya, I'm an ese loco so I get backstage passes!
by AcidHead October 27, 2007
A small, hairy gay man, often found sporting dark facial stubble and a bushy moustache.
That Mike, he's such a loco ese. I wouldn't be surprised to see him bending for a friend.
by SenorMinge October 15, 2010