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in spite of everything; without regard to drawbacks....Having no regard; heedless; careless; as, regardless of life, consequences, dignity.....Not regarded; slighted.....Means the same as regardless, just an appropriate way of saying irregardless (as commonly spelled) without actually contradicting the word regardless, as adding the prefix "ir" would.
He ate the rotten apples earegardless of the warnings given to him by his doctor.
by SDB72083LRAR12009 January 20, 2009
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