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It's when HIV negative men ingest a comprehensive anti-retroviral drug, like tenofivir, before having risky bareback sex in an attempt to lower the risk of HIV infection. The theory is that anti-retroviral drugs prevent the HIV virus from attaching to healthy cells and replicating.
"I'm disco dosing my way through this sex party later."

"I'm high as fuck on crystal right now, and I had a pretty unhappy childhood, so, yeah, sure, I'll try disco dosing."
by tf666 July 23, 2009
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