Diapukus Share definition Flag (die•a•PUKE•us) noun Diarrhea and vomiting. Usually occurring at the same time. Those clams we ate last night must have been bad because everybody in the house came down with diapukus this morning. Diapukus by Worker 11811 February 11, 2009 0 0 Get merch Get the Diapukus mug. Buy Now — $32.95 See more merch