When you do uppers and downers at the same time, particularly meth and marijuana, but can typically refer to energy drinks as well.
I rolled a bowl and smoked a jank the other day and got crosswired as hell.
by DysFunK Smith February 21, 2010
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Having caffeine and marijuana at the same time. Comes from “crossfaded” + “wired”.
When I was crosswired this morning, I was peacefully coloring a picture, but also felt so jittery I wanted to snap the crayon in half.
by gingerfish27 August 10, 2022
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A selfish, spoiled rich monkey from the children's television show, Arthur. She is very fashionable, stubborn, beautiful, and extremely wealthy. Even though Muffy is all of these things, she is very misunderstood. She boasts confidence when on the inside, she lacks the confidence she shows to her fellow third grade classmates. In addition to that, she happens to be friendly when she feels compelled to and genuinely cares about her friends.

It is a rarity to be compared to Muffy Crosswire, for it can be seen as rude, but in hindsight, it is an honor to be compared to such a mature eight year old anthropomorphic monkey from one of the most beloved children's television shows of all time.
Ugh, she is so annoying, just like Muffy Crosswire, but she is also so chic and fashionable.
by regan/muffy August 27, 2016
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