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(1) Internal intestine erruption due to the instant tightning of the anus. This deadly virus has been known to strike fags, bullshitters, jack-asses, dumb-assess, and assholes world-wide. But the most common cause is that fucking bitch debby.

(2) The locking of the anus intentionally to prevent any unwanted items from entering or escaping. Normally used in conjuction with a jerksqueeze or the lock-n-pop.
(1) It was determined that Bob, after all that shit talk, was infected with colon lock and would die a pretty shitty death.

(2) Colon lock is a widly used technique in prison and has been known to reduce the risk of gayness.
by whitestrips April 28, 2008
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