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A complete transformation of someone's personality and attitude after they have taken time away from their usual routine, or have had some type of life-changing experience.
"Our department manager was so nice, friendly and reasonable after she attended that weekend retreat. It was as if she had a character transplant."

"Bill is so different after beating cancer, then taking that long vacation. He must have had a character transplant."
by yes juanito yes August 30, 2014
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