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break through 

To smoke enough DMT for a very immersive and intense trip, usually lasts around 15 minutes and in which almost all connection to the real world is lost. Many who have broken through describe it as a life changing experience, but other than that the trip is indescribable.
Yo man I got some DMT u wanna break through tonight?
Nah man I did last night, that was some freaky shit.
break through by dsltmd November 2, 2011
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break through 

When wiping and one puntures the toilet paper causing a little stink finger
I was wiping my ass and had a little break through and got some shit on my fingers.
break through by Ivan Wackenoff October 19, 2004

Break through sex 

It’s break up sex, but you are not dating. It is the last time you two have sex.
Charlie: yo, last night together

Lily: we need to make it memorable

Charlie: we should have break through sex
Break through sex by Yoloerrrrrrr January 23, 2022

blackout breakthrough 

After a good night of binge drinking, in which you blackout, there comes a moment of clarity the next day, where you are finally able to recant on the previous nights shenanigans.
ArJay, "Damn Jimmy I was soo hammered last night I just remembered that Bobby got Iced by a fifty year old lady!"

Jimmy, "I totally forgot about that one too. Great blackout breakthrough"
blackout breakthrough by ArJizzld August 18, 2010

Breakthrough 

The full transcendence of one's consciousness into another dimension through the medium of certain psychedelic drugs. These psychedelic breakthroughs are achieved mainly through very high doses of DMT, salvia divinorum, amanita muscaria mushrooms, ibogaine, or psilocybin.
After I took three very large inhalations of DMT I experienced a breakthrough into the sacred realm known as Hyperspace.
Breakthrough by Metatronix October 27, 2009

Breakthrough Manchester 

A great program held at the Derryfield School in Manchester NH.You apply in fifth grade , spend the next 2 summers there and a few schooldays a month.It has changed my life enourmously.Formerly Summerbridge.
Me-I went to Breakthrough Manchester
Freind-NERD

five years later

Me-I found a cure for cancer
Freind-do ya want fries with that?

Breakthrough 

During extreme impaction constipation, enemas and oral laxatives must be used. Breakthrough occurs when you finally shit out the last of the acorns and the diarrhea from your oral laxatives finally breaks through the fist sized corm of fecal clumps you were trying to squeeze out of your dry, fissured anus, giving you that sweet relief of liquid diarrhœa. Usually accompanied by uncontrollable vomiting.
To the photo lab technician in Walgreens: Those enemas and laxatives really helped me achieve breakthrough last night.